From the Guidelines
Penile enlargement in adults is often a temporary condition related to sexual arousal, inflammation, or other factors, and not a cause for concern unless accompanied by pain, unusual discharge, or other symptoms. If you're experiencing unexpected penile growth as an adult, it's essential to consult a healthcare provider to rule out any underlying medical conditions. Some medical conditions like Peyronie's disease can cause changes in penile appearance, as noted in the AUA guideline on Peyronie's disease 1. Weight loss can also make the penis appear larger by reducing fat in the pubic area. There's no medically approved method to permanently increase penis size beyond natural development. It's crucial to prioritize your health and consult a healthcare provider if you have any concerns about your penis or overall health, as they can provide personalized advice and treatment, as recommended in the AUA guideline on erectile dysfunction 1. In some cases, penile curvature or deformity may be a sign of an underlying condition, and treatment options such as tunical plication surgery or plaque incision and/or excision with grafting may be considered, as discussed in the AUA guideline on Peyronie's disease 1. However, these treatments should only be considered under the guidance of a qualified healthcare provider. Ultimately, if you're concerned about your penis or overall health, consulting a healthcare provider is the best course of action to determine the cause of any changes and receive appropriate treatment and guidance.
From the FDA Drug Label
When administered to rats at 200 mg/kg/day between gestation days 13 and 21 (late embryogenesis and fetal development), feminization of male fetuses was observed Offspring exposed during late pregnancy to 50 mg/kg/day and 100 mg/kg/day doses of spironolactone exhibited changes in the reproductive tract including dose-dependent decreases in weights of the ventral prostate and seminal vesicle in males, ovaries and uteri that were enlarged in females, and other indications of endocrine dysfunction, that persisted into adulthood Spironolactone can cause gynecomastia. In a Randomized Spironolactone Evaluation Study, patients with heart failure treated with a mean dose of 26 mg of spironolactone once daily, about 9% of the male subjects developed gynecomastia.
The penis getting larger is not directly mentioned in the provided drug labels. However, gynecomastia (enlargement of breast tissue in males) is mentioned as a possible side effect of spironolactone 2 2.
- Gynecomastia can be associated with hormonal imbalances, which may also affect other parts of the reproductive system.
- The provided information does not directly support the conclusion that spironolactone causes the penis to get larger.
- It is essential to consult a healthcare professional for a proper evaluation and advice regarding any changes in the reproductive system.
From the Research
Possible Reasons for Increase in Penis Size
- There is evidence to suggest that the average erect penis length has increased over the past three decades across the world 3.
- A study found that erect length increased significantly over time in several regions of the world and across all age groups, with an increase of 24% over the past 29 years after adjusting for geographic region, subject age, and subject population 3.
Factors to Consider
- Penile size can be influenced by various factors, including geographic region, subject age, and subject population 3.
- There is significant interobserver variability in penile length assessment, which can lead to inaccurate measurements 4.
- Flaccid measurements can underestimate erect size, with a mean underestimate of 2.64 cm (21.4%) and girth 2.27 cm (19.5%) 4.
Importance of Accurate Measurements
- Erect penis measurements should be used for men being considered for treatment of small penis anxiety 4.
- A thorough biopsychosocial and multidisciplinary assessment is required for men with concerns about penis size 5.
- Treatment of men with concerns about penis size should start with a thorough biopsychosocial assessment, followed by extensive psychoeducation, counselling, and psychological interventions, even if surgery is being considered 5.