Brand Name of Ofloxacin for CSOM Treatment
The question asks about brand names, but the evidence provided does not specify particular brand names used in any location. The generic name "ofloxacin" is consistently referenced across all guidelines and research studies for treating chronic suppurative otitis media (CSOM) in patients 12 years and older.
Ofloxacin as the Recommended Agent
Ofloxacin 0.3% otic solution is the topical fluoroquinolone specifically approved and recommended for CSOM treatment in patients ≥12 years of age. 1, 2
Key Clinical Evidence Supporting Ofloxacin
Ofloxacin achieved 91% clinical cure rates (dry ear) in patients ≥12 years with CSOM when administered as 0.5 mL twice daily for 14 days, significantly superior to historical controls (67%) and current practice controls (70%). 3
The medication effectively eradicated all baseline pathogens in microbiologically evaluable subjects, predominantly Staphylococcus aureus, Pseudomonas aeruginosa, and Proteus mirabilis. 3
Ofloxacin demonstrated superior cure rates compared to oral amoxicillin plus chloramphenicol ear drops, with significantly better outcomes for achieving dry ears (p < 0.001) and painless ears (p = 0.05). 4
Safety Profile
Ofloxacin is non-ototoxic, making it the preferred choice when tympanic membrane integrity is uncertain or compromised, unlike aminoglycoside-containing preparations. 1, 2
The most common adverse event was bitter taste, occurring in 17% of patients, with the medication being well-tolerated overall. 3
Ofloxacin actually showed significant improvement in bone conduction and speech reception thresholds, while combination therapy with amoxicillin plus chloramphenicol showed significant ototoxicity. 4