From the Guidelines
Lisinopril 40mg is approximately equivalent to losartan 100mg in terms of blood pressure lowering effects. When switching between these medications, losartan 100mg daily would be the appropriate equivalent dose to lisinopril 40mg daily, as indicated by the most recent guidelines 1. These medications work differently - lisinopril is an ACE inhibitor while losartan is an angiotensin II receptor blocker (ARB) - but they both affect the renin-angiotensin-aldosterone system to lower blood pressure.
- Key points to consider when switching between these medications include:
- Individual responses to these medications can vary, so blood pressure should be monitored closely after switching 1.
- The transition between these medications typically doesn't require tapering; however, a healthcare provider should supervise any medication change.
- Losartan may be preferred in patients who experience ACE inhibitor-induced cough, as ARBs rarely cause this side effect.
- The maximum recommended dose of losartan is 100mg daily, while lisinopril can be prescribed up to 40mg daily for hypertension, as per the guidelines 1. It's also worth noting that the 2020 ACC/AHA clinical performance and quality measures for adults with heart failure recommend losartan 100mg as the target dose 1.
From the Research
Equivalent Dosing of Lisinopril and Losartan
- The provided studies do not directly compare the equivalent dosing of lisinopril and losartan 2, 3.
- However, the studies suggest that losartan 100mg is a common dose used in the treatment of hypertension 3.
- Lisinopril 10mg and 20mg doses are mentioned in the study, but no direct comparison to losartan 40mg is made 2.
- There is no clear equivalent dose of losartan for lisinopril 40mg based on the provided evidence.
- The studies focus on the efficacy and safety of different dosing regimens of lisinopril and losartan, rather than providing a direct comparison of their equivalent doses 2, 3.