From the Guidelines
Discontinuation of Lexapro can lead to increased hunger in some individuals due to the withdrawal effects associated with stopping SSRI antidepressants. When considering the discontinuation of Lexapro, it's crucial to understand that SSRIs, including Lexapro (escitalopram), can cause a discontinuation syndrome characterized by various symptoms, including dizziness, fatigue, and changes in appetite 1. Although the provided evidence does not directly mention Lexapro in the context of increased hunger upon discontinuation, it discusses the potential for discontinuation syndrome with shorter-acting SSRIs, notably paroxetine, and to a lesser extent, fluvoxamine and sertraline 1. Given that Lexapro is also an SSRI, albeit not explicitly mentioned in the context of hunger, the principle of cautious discontinuation to avoid withdrawal symptoms applies. Key points to consider include:
- The potential for withdrawal symptoms when discontinuing SSRIs, which can include changes in appetite and hunger.
- The importance of gradual tapering when stopping SSRIs to minimize withdrawal effects, as abrupt discontinuation can exacerbate these symptoms.
- Monitoring for symptoms, especially in the first 24 to 48 hours after dosage changes, as recommended for starting or adjusting serotonergic drugs 1. If you're planning to stop Lexapro, it is recommended to do so under medical supervision with a gradual tapering schedule to minimize withdrawal effects, including potential changes in appetite and hunger.
From the Research
Discontinuation of Lexapro and Increased Hunger
- There is no direct evidence in the provided studies that discontinuation of Lexapro (escitalopram) causes increased hunger 2, 3, 4, 5, 6.
- The studies primarily focus on the effects of escitalopram on depression, anxiety, and other psychological conditions, but do not mention hunger or appetite as a side effect of discontinuation.
- Some studies discuss the efficacy and tolerability of escitalopram compared to other antidepressants, but do not report any information on hunger or appetite changes 3, 4, 5.
- One study investigates the effects of escitalopram on behavioral flexibility and inhibition of prepotent responding, but does not mention hunger or appetite 6.
- Another study examines the effects of escitalopram on aldosterone and renin levels, but does not discuss hunger or appetite 2.