From the Research
If you're experiencing statin-induced nerve pain, consult your healthcare provider promptly to discuss potential treatment adjustments, such as reducing your dose, switching to a different statin, or trying a statin holiday. The management of statin-induced nerve pain, also known as peripheral neuropathy, involves a thorough assessment of the patient's symptoms and medical history. According to the most recent evidence 1, primary treatments for neuropathic pain include selective serotonin-norepinephrine reuptake inhibitors (SNRIs) such as duloxetine and venlafaxine, gabapentin, tricyclic antidepressants, as well as topical lidocaine and transcutaneous electrical nerve stimulation. Some key points to consider in the management of statin-induced nerve pain include:
- Reducing the statin dose or switching to a different statin may help alleviate symptoms
- Alternative cholesterol-lowering medications like ezetimibe or PCSK9 inhibitors might be considered if statin-related nerve pain persists
- Taking CoQ10 supplements (100-200mg daily) may help reduce statin side effects, as statins can deplete this compound in the body
- The nerve pain typically presents as burning, tingling, or numbness in the extremities and occurs because statins can occasionally interfere with nerve function by affecting cell membranes or mitochondrial activity
- Most cases of statin-induced nerve pain are reversible when the medication is adjusted or discontinued, but early intervention is important to prevent long-term nerve damage. It's essential to weigh the benefits and risks of statin therapy and consider alternative treatments for managing cholesterol levels, as suggested by studies 2, 3, 4, 5.