From the Guidelines
Insulin lispro's effect lasts for approximately 3 to 4 hours, as indicated by its duration of action. This rapid-acting insulin analog has an onset of action within 5 minutes and peaks between 1 to 2 hours after injection 1. The duration of insulin lispro's effect is a crucial factor in managing postprandial blood glucose levels, and its short duration distinguishes it from other types of insulin. Some key characteristics of insulin lispro include:
- Onset of action: 5 minutes
- Peak action: 1 to 2 hours
- Duration of action: 3 to 4 hours As noted in the study published in the American Family Physician 1, the rapid-acting nature of insulin lispro makes it effective for controlling postprandial blood glucose, but it also increases the risk of hypoglycemia if not managed properly. To manage blood glucose levels effectively with insulin lispro, patients should:
- Time their injections shortly before meals
- Monitor their blood glucose levels regularly to understand their personal response pattern
- Be aware that they may need additional insulin doses for subsequent meals as the effect wears off
- Consider combining insulin lispro with a longer-acting insulin for complete 24-hour coverage.
From the Research
Insulin Lispro Effect Duration
- The duration of activity of insulin lispro is less than five hours 2.
- Insulin lispro begins to exert its effects within 15 minutes of subcutaneous administration, and peak levels occur 30 to 90 minutes after administration 2.
- There is no direct information in the other studies regarding the exact duration of insulin lispro's effect, as they focus on comparisons with other insulins or treatment regimens 3, 4, 5, 6.
- However, these studies demonstrate the efficacy and safety of insulin lispro in various treatment regimens, including its use in combination with other insulins or medications 3, 4, 5, 6.