From the Research
I do not recommend taking hydroxychloroquine with oral minoxidil without medical supervision due to potential interactions. Both medications can affect your heart rhythm, and when taken together, they may increase the risk of QT interval prolongation, which can lead to dangerous irregular heartbeats. Hydroxychloroquine is typically prescribed for autoimmune conditions like lupus or rheumatoid arthritis, or for malaria, while oral minoxidil is used for severe hypertension or hair loss. These medications can also individually cause side effects like low blood pressure, dizziness, or fluid retention, which might be compounded when taken together.
According to a study published in the Journal of cosmetic dermatology 1, hydroxychloroquine and finasteride are equally effective, safe, and well-tolerable for treating frontal fibrosing alopecia patients, and both groups received topical minoxidil, indicating that minoxidil can be safely used with other medications. However, the safety of combining hydroxychloroquine with oral minoxidil is not explicitly stated in this study.
Another study published in The Journal of dermatological treatment 2 provides a comprehensive review of minoxidil, including its mechanism of action, pharmacokinetics, and clinical efficacy, but does not discuss potential interactions with hydroxychloroquine.
Additionally, a systematic review and meta-analysis published in Aesthetic plastic surgery 3 found that the combination of finasteride and topical minoxidil has better therapeutic efficacy than monotherapy for androgenetic alopecia, but again, does not address the safety of combining hydroxychloroquine with oral minoxidil.
Given the potential risks and lack of explicit guidance on the safety of combining hydroxychloroquine with oral minoxidil, it is essential to consult with a healthcare provider before taking these medications together. They can evaluate your specific medical history, current health status, and other medications you may be taking to determine if this combination is safe for you.