From the Research
Augmentin (amoxicillin/clavulanate) is not typically associated with a significant increase in heart rate, according to the most recent and highest quality study available 1. This study, published in 2022, compared the cardiovascular mortality associated with azithromycin versus amoxicillin-clavulanate among US Veterans treated for respiratory infection, and found no significant difference in the risk of cardiovascular death between the two antibiotics. While Augmentin can cause tachycardia (increased heart rate) as a side effect in rare cases, this may occur as part of an allergic reaction to the medication, which would be accompanied by other symptoms like rash, itching, or difficulty breathing. Some key points to consider:
- Augmentin can also cause anxiety in some people, which might indirectly lead to an increased heart rate.
- If you notice a significant or persistent increase in heart rate while taking Augmentin, you should contact your healthcare provider promptly, especially if accompanied by chest pain, shortness of breath, or feeling faint.
- Most people tolerate Augmentin without cardiovascular side effects, but individual responses to medications can vary based on factors like age, overall health, and other medications being taken concurrently. It's worth noting that other studies have investigated the cardiovascular risks associated with different antibiotics, including azithromycin and clarithromycin 2, 3, but the most recent and highest quality study available 1 provides the most relevant evidence for Augmentin.