Wegovy Pen Dosing
Each Wegovy pen contains a single dose of semaglutide—one pen delivers one injection.
Pen Configuration and Dosing
Wegovy is supplied as single-dose, pre-filled pens, with each pen containing one specific dose strength for subcutaneous injection once weekly 1, 2.
The medication follows a 16-week titration schedule with different pen strengths used at each phase: 0.25 mg weekly for weeks 1-4,0.5 mg weekly for weeks 5-8,1.0 mg weekly for weeks 9-12,1.7 mg weekly for weeks 13-16, and finally the maintenance dose of 2.4 mg weekly starting at week 17 1, 2.
Each pen is designed for single use only—after administering the dose, the pen should be discarded 2.
Practical Prescribing Considerations
Patients will need four pens per month once they reach the maintenance dose of 2.4 mg weekly (one pen per week) 1.
During the titration phase, prescriptions should specify the exact dose strength needed for that 4-week period, as each titration step requires pens of a different strength 1, 2.
The gradual dose escalation over 16 weeks is essential to minimize gastrointestinal adverse effects, which occur in 17-44% of patients but are typically mild-to-moderate and transient 1.
Common Pitfall to Avoid
- Do not confuse Wegovy pens with multi-dose insulin pens—Wegovy pens are single-dose devices, whereas some insulin delivery systems contain multiple doses 3. Each Wegovy injection requires a new pen.