What is the cause of abnormal vaginal bleeding and pelvic pain in a woman with a progestin-releasing IUD and negative pregnancy test?

Medical Advisory BoardAll articles are reviewed for accuracy by our Medical Advisory Board
Educational purpose only • Exercise caution as content is pending human review
Article Review Status
Submitted
Under Review
Approved

Last updated: April 14, 2025View editorial policy

Personalize

Help us tailor your experience

Which best describes you? Your choice helps us use language that's most understandable for you.

Differential Diagnosis for Abnormal Vaginal Bleeding and Pelvic Pain

  • Single most likely diagnosis
    • Perforation of the uterus by the IUD: This is a possible complication of IUD insertion, especially given the patient's history of amenorrhea followed by vaginal spotting and the development of constant pelvic pain. The presence of uterine tenderness on examination supports this diagnosis.
  • Other Likely diagnoses
    • Infection or pelvic inflammatory disease (PID): The patient's symptoms of pelvic pain, uterine and adnexal tenderness, and vaginal spotting could be indicative of an infection, possibly related to the IUD.
    • IUD malposition: If the IUD is not properly positioned, it could cause symptoms like pelvic pain and vaginal bleeding.
    • Ovarian cysts: These can cause pelvic pain and are common in women of reproductive age. The adnexal tenderness noted on examination could suggest an ovarian cyst.
  • Do Not Miss (ddxs that may not be likely, but would be deadly if missed.)
    • Ectopic pregnancy: Although the urine pregnancy test is negative, it's crucial to consider ectopic pregnancy due to its potentially life-threatening nature. A negative test does not entirely rule out pregnancy, especially if it's very early.
    • Appendicitis: While less directly related to the IUD or vaginal bleeding, appendicitis can present with pelvic pain and must be considered due to its potential for serious complications if not promptly treated.
  • Rare diagnoses
    • Uterine or cervical cancer: Although rare in a 24-year-old, any abnormal vaginal bleeding warrants consideration of malignancy, especially if other causes are ruled out.
    • Endometriosis: This condition can cause pelvic pain and abnormal bleeding, though it might not directly relate to the IUD's presence. It's less likely given the patient's age and the specific context of IUD use but remains a consideration for chronic pelvic pain.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

Have a follow-up question?

Our Medical A.I. is used by practicing medical doctors at top research institutions around the world. Ask any follow up question and get world-class guideline-backed answers instantly.