From the Guidelines
Recent RCTs for Benign Esophageal Disease and Benign Gallbladder Disease
The most recent RCTs for benign esophageal disease include studies on radiofrequency ablation (RFA) for Barrett's esophagus with low-grade dysplasia, and anti-reflux surgery compared to medical treatment with PPIs 1. Unfortunately, there is no recent RCT evidence provided for benign gallbladder disease.
Benign Esophageal Disease RCTs
- Radiofrequency Ablation (RFA): Three RCTs showed a clinically important benefit of RFA compared to endoscopic surveillance for complete eradication of dysplasia and intestinal metaplasia in patients with Barrett's esophagus and low-grade dysplasia 1.
- Anti-Reflux Surgery: Two small RCTs compared anti-reflux surgery (Nissen fundoplication) with esomeprazole, showing no clinically important difference in progression to high-grade dysplasia, but a clinically important benefit of medical treatment for complications 1.
- Other Ablation Techniques: There is no recent RCT evidence to support the use of other ablation techniques, such as cryotherapy, for treating low-grade dysplasia in Barrett's esophagus 1.
Benign Gallbladder Disease RCTs
No recent RCT evidence is provided for benign gallbladder disease.
Note: The evidence provided is limited to benign esophageal disease, and there is no information available on recent RCTs for benign gallbladder disease.
From the Research
Benign Esophageal Disease
- There are no recent Randomized Controlled Trials (RCTs) specifically for benign esophageal disease mentioned in the provided studies 2, 3, 4, 5.
- However, a study from 2011 6 investigated the relationship between impaired gallbladder function and the development of Barrett's esophagus and esophageal adenocarcinoma, which may be relevant to benign esophageal disease.
- The study found that gallbladder function is progressively impaired in Barrett's esophagus and adenocarcinoma, which may contribute to the development of these conditions 6.
Benign Gallbladder Disease
- There are no recent RCTs specifically for benign gallbladder disease mentioned in the provided studies 2, 3, 4, 5.
- A study from 2011 6 compared gallbladder function in patients with Barrett's esophagus, adenocarcinoma, and controls, and found that impaired gallbladder function may contribute to duodenogastric reflux and harmful GERD.
- However, this study did not specifically investigate benign gallbladder disease, and there is no other evidence provided to support the existence of recent RCTs for this condition 2, 3, 4, 5.