Are there any clinical trials demonstrating the benefit of using vitamin C (ascorbic acid) in the treatment of Coronavirus disease 2019 (COVID-19)?

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Last updated: April 14, 2025View editorial policy

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From the Research

Vitamin C should not be recommended as a standard treatment for COVID-19 outside of clinical trials due to limited and inconsistent evidence of its benefits. The use of vitamin C in COVID-19 has been investigated in several studies, but the results are mixed and do not provide strong evidence for its effectiveness in preventing or treating the disease [ 1 ]. Some studies suggest that high-dose intravenous vitamin C may have potential benefits in reducing inflammatory markers and improving oxygenation in hospitalized COVID-19 patients [ 2 ]. However, larger and more rigorous trials are needed to confirm these findings and establish the safety and efficacy of vitamin C in COVID-19 treatment.

Key points to consider:

  • The evidence for vitamin C in COVID-19 is limited and inconsistent [ 3 ]
  • High-dose intravenous vitamin C may have potential benefits in reducing inflammation and improving oxygenation [ 1 ]
  • Larger and more rigorous trials are needed to establish the safety and efficacy of vitamin C in COVID-19 treatment [ 4 ]
  • Vitamin C supplementation should only be considered under medical supervision due to potential side effects and interactions [ 5 ]

In terms of morbidity, mortality, and quality of life, the current evidence does not support the routine use of vitamin C in COVID-19 prevention or treatment. However, ongoing research and clinical trials may provide more insight into the potential benefits and risks of vitamin C supplementation in COVID-19 patients.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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