Clinical Significance of Absolute Lymphocyte Count of 1333
An absolute lymphocyte count of 1333 cells/μL in an asymptomatic adult with no significant medical history is within the normal reference range and requires no intervention. 1
Normal Reference Range
- Normal absolute lymphocyte counts in adults typically range between 1000-4800 cells/μL, with laboratory-specific variations. 1
- Your value of 1333 cells/μL falls comfortably within this normal range and does not indicate any pathology. 1
What This Value Rules Out
Chronic Lymphocytic Leukemia (CLL):
- CLL diagnosis requires an absolute lymphocyte count exceeding 5000 cells/μL of mature-appearing lymphocytes in peripheral blood. 1
- Your count is far below this threshold, effectively excluding CLL as a consideration. 2, 1
- Even in rare cases of "CLL with low lymphocyte count," the minimum threshold is 1500 cells/μL with persistent relative lymphocytosis ≥50% in patients over 50 years old. 3
Lymphocytopenia:
- Lymphocytopenia in adults is defined as counts <1500/mm³. 4
- Your count of 1333 cells/μL is just below this threshold but in an asymptomatic patient without risk factors (no immunosuppressive therapy, no autoimmune disease, no infections), this represents normal variation rather than pathologic lymphocytopenia. 4
Clinical Recommendations
No action is required for this isolated finding in an asymptomatic patient. 1
- The American Society of Hematology recommends avoiding over-interpretation of isolated normal laboratory values without clinical context. 1
- Serial measurements would only be informative if monitoring for specific disease progression or treatment response in established conditions. 1
When to Reconsider
Repeat testing would be warranted only if: