Can blurred vision and diplopia (double vision) affect Visual Related Quality of Life (VRQOL)?

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Last updated: April 14, 2025 • View editorial policy

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From the FDA Drug Label

  1. 1 Spread of Toxin Effect Postmarketing safety data from other approved botulinum toxins suggest that botulinum toxin effects may be observed beyond the site of local injection The symptoms are consistent with the mechanism of action of botulinum toxin and may include asthenia, generalized muscle weakness, diplopia, ptosis, dysphagia, dysphonia, dysarthria, urinary incontinence, blurred vision, and breathing difficulties.

The symptoms of blurred vision and double vision (diplopia) can affect VRQOL, as they are potential side effects of botulinum toxin injection, including JEUVEAU 1.

From the Research

Blurred vision and double vision can significantly impact Vision-Related Quality of Life (VRQOL), as evidenced by the most recent study in 2025, which found that single and multiple visual function impairments, including contrast sensitivity and depth perception, are associated with decreased VRQOL in older adults 2.

Key Points

  • Visual disturbances such as blurred vision and double vision can interfere with daily activities, leading to decreased independence and increased frustration.
  • These symptoms can stem from various conditions, including refractive errors, cataracts, dry eye, neurological disorders, or muscle imbalances.
  • Treatment depends on the underlying cause and may include corrective lenses, prism glasses, eye patches, vision therapy, medications, or surgery.
  • Prompt medical attention is crucial, as these symptoms can significantly impact psychological well-being, causing anxiety, depression, and social withdrawal.
  • The study by 2 found that contrast sensitivity had the largest contribution to the decline in overall VRQOL, highlighting the importance of comprehensive visual function testing.

Impact on VRQOL

  • The study by 2 demonstrated that bilateral single and multiple visual function impairments are prevalent in older adults and can systematically worsen VRQOL scores.
  • Another study by 3 found that high contrast visual acuity and contrast sensitivity are two important factors affecting VRQOL in patients with advanced age-related macular degeneration.
  • The impact of blurred vision and double vision on VRQOL is not limited to visual function, as it can also affect psychological well-being, social interactions, and overall quality of life.

Recommendations

  • Comprehensive visual function testing is warranted to prevent the debilitating consequences of visual function impairments on healthy aging.
  • Prompt medical attention is essential to address the underlying cause of blurred vision and double vision and to prevent further decline in VRQOL.
  • Treatment should be tailored to the individual's specific needs, taking into account the underlying cause and the impact on VRQOL.

References

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Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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