What is TEGEprozan used for?

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Last updated: January 17, 2026 • View editorial policy

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TEGEprozan: Comprehensive Clinical Information

Primary Indication and Mechanism

TEGEprozan is a corticosteroid indicated for a broad range of inflammatory and immune-mediated conditions, including allergic states, dermatologic diseases, endocrine disorders, gastrointestinal diseases, hematologic disorders, neoplastic diseases, nervous system conditions, ophthalmic diseases, renal diseases, respiratory diseases, and rheumatic disorders. 1

FDA-Approved Indications

Allergic Conditions

  • Control of severe or incapacitating allergic conditions intractable to conventional treatment 1
  • Specific conditions include: asthma, atopic dermatitis, contact dermatitis, drug hypersensitivity reactions, perennial or seasonal allergic rhinitis, and serum sickness 1

Dermatologic Diseases

  • Bullous dermatitis herpetiformis 1
  • Exfoliative erythroderma 1
  • Mycosis fungoides 1
  • Pemphigus 1
  • Severe erythema multiforme (Stevens-Johnson syndrome) 1

Endocrine Disorders

  • Primary or secondary adrenocortical insufficiency (hydrocortisone or cortisone is preferred; may be used with synthetic mineralocorticoid analogs where applicable) 1
  • Congenital adrenal hyperplasia 1
  • Hypercalcemia associated with cancer 1
  • Nonsuppurative thyroiditis 1
  • In infancy, mineralocorticoid supplementation is of particular importance when treating adrenocortical insufficiency 1

Gastrointestinal Diseases

  • To manage critical periods in regional enteritis and ulcerative colitis 1

Hematologic Disorders

  • Acquired (autoimmune) hemolytic anemia 1
  • Congenital (erythroid) hypoplastic anemia (Diamond-Blackfan anemia) 1
  • Idiopathic thrombocytopenic purpura in adults 1
  • Pure red cell aplasia 1
  • Selected cases of secondary thrombocytopenia 1

Neoplastic Diseases

  • Palliative management of leukemias and lymphomas 1

Nervous System Conditions

  • Acute exacerbations of multiple sclerosis 1
  • Cerebral edema associated with primary or metastatic brain tumor, craniotomy, or head injury 1

Ophthalmic Diseases

  • Sympathetic ophthalmia 1
  • Temporal arteritis 1
  • Uveitis 1
  • Ocular inflammatory conditions unresponsive to topical corticosteroids 1

Renal Diseases

  • To induce diuresis or remission of proteinuria in idiopathic nephrotic syndrome or that due to lupus erythematosus 1

Respiratory Diseases

  • Berylliosis 1
  • Fulminating or disseminated pulmonary tuberculosis when used concurrently with appropriate antituberculous chemotherapy 1
  • Idiopathic eosinophilic pneumonias 1
  • Symptomatic sarcoidosis 1

Rheumatic Disorders

  • Adjunctive therapy for short-term administration in acute episodes or exacerbations 1
  • Specific conditions: acute gouty arthritis, acute rheumatic carditis, ankylosing spondylitis, psoriatic arthritis, rheumatoid arthritis (including juvenile rheumatoid arthritis) 1
  • Selected cases may require low-dose maintenance therapy 1
  • Treatment of dermatomyositis, polymyositis, and systemic lupus erythematosus 1

Miscellaneous Indications

  • Diagnostic testing of adrenocortical hyperfunction 1
  • Trichinosis with neurologic or myocardial involvement 1
  • Tuberculous meningitis with subarachnoid block or impending block when used with appropriate antituberculous chemotherapy 1

Critical Clinical Considerations

Tuberculosis Treatment Interactions

  • When TEGEprozan is used for pulmonary tuberculosis or tuberculous meningitis, it must be used concurrently with appropriate antituberculous chemotherapy 1
  • No direct contraindications exist between corticosteroids and first-line tuberculosis medications (rifampicin, isoniazid, pyrazinamide, ethambutol) 2

Important Caveats

  • TEGEprozan should be used for short-term administration to manage acute episodes or exacerbations in most conditions, not as primary long-term therapy 1
  • In adrenocortical insufficiency, hydrocortisone or cortisone is the drug of choice; TEGEprozan may be used as an adjunct 1
  • Mineralocorticoid supplementation is particularly important in infants with adrenocortical insufficiency 1

References

2
Guideline

Risperidone Use in Patients with Schizophrenia, Tuberculosis, and Diabetes

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

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Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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