Proov Pro Supplement Safety with Prescription Progesterone
There is no evidence-based information available about "Proov Pro" as a supplement, and I cannot recommend combining any unregulated supplement with prescription progesterone without knowing its specific ingredients and formulation.
What We Know About Proov Products
The only evidence-based Proov product is Proov Complete, which is a hormone testing system (not a supplement) that measures FSH, E1G, LH, and PdG levels to predict fertile windows and confirm ovulation 1. This is a diagnostic tool, not a therapeutic supplement 1.
Critical Safety Considerations
If "Proov Pro" Contains Progesterone or Progestins:
Do not combine over-the-counter progesterone products with prescription progesterone without explicit physician approval, as this creates several risks:
- Excessive progesterone exposure increases risks of cardiovascular events, including 12 additional DVTs per 10,000 woman-years and 9 additional strokes per 10,000 woman-years in women using combined hormone therapy 2
- Unregulated dosing from supplements lacks the quality control and standardization of prescription formulations 3
- Interference with fertility treatment efficacy may occur if dosing becomes supraphysiologic or timing is disrupted 4, 5
Prescription Progesterone Dosing for Fertility
Your prescription progesterone regimen should follow evidence-based protocols 5:
- For recurrent miscarriage/early pregnancy bleeding: Vaginal micronized progesterone 400 mg twice daily, or 90-mg gel daily, or 200-mg suppository daily 5
- For preterm birth prevention (if prior spontaneous preterm birth): 17P 250 mg IM weekly from 16-20 weeks until 36 weeks 4, 5
- For short cervix without prior preterm birth: Vaginal progesterone 90-mg gel or 200-mg suppository daily from diagnosis until 36 weeks 5
What You Should Do
Immediately disclose all supplements to your prescribing physician, including the complete ingredient list of "Proov Pro" 2. Your physician needs to:
- Verify there are no progesterone or progestin compounds in the supplement
- Check for potential interactions with your prescription regimen
- Ensure the supplement doesn't contain ingredients that could interfere with fertility treatment outcomes
Safe Supplement Combinations
Magnesium glycinate can be safely combined with progesterone without documented negative interactions, and may complement hormone therapy 6. However, this does not extend to unknown proprietary formulations 6.
Red Flags to Avoid
- Never self-prescribe additional progesterone beyond your prescription dose 2
- Avoid supplements claiming to "boost" or "support" progesterone without physician review, as these may contain phytoprogestins or actual hormones 2
- Do not use progesterone if you have multiple cardiovascular risk factors without careful medical supervision (Category 2-3 risk) 2