From the FDA Drug Label
When discontinuing pregabalin, taper gradually over a minimum of 1 week [see WARNINGS AND PRECAUTIONS (5. 6)]. If pregabalin is discontinued, taper the drug gradually over a minimum of 1 week rather than discontinue the drug abruptly.
Weaning Lyrica (Pregabalin): The recommended approach is to taper gradually over a minimum of 1 week to minimize the potential of increased seizure frequency in patients with seizure disorders and to reduce the risk of withdrawal symptoms such as insomnia, nausea, headache, anxiety, hyperhidrosis, and diarrhea 1.
From the Research
Weaning off Lyrica (pregabalin) should be done gradually under medical supervision to minimize withdrawal symptoms, with a typical tapering schedule involving reducing the dose by 25-50mg every 7 days until discontinuation, as supported by the most recent and highest quality study available 2. When considering weaning off Lyrica, it's essential to prioritize a gradual tapering schedule to minimize potential withdrawal symptoms, such as anxiety, insomnia, nausea, pain, sweating, and in rare cases, seizures.
- The tapering schedule should be individualized based on the patient's current dose, duration of treatment, and individual response to the medication.
- For example, if a patient is taking 300mg of Lyrica daily, a possible tapering schedule could involve reducing the dose to 250mg daily for one week, then 200mg daily for one week, and continuing this pattern until reaching zero.
- It's crucial to stay in contact with a healthcare provider during the weaning process to report any concerning symptoms and adjust the tapering schedule as needed.
- Lyrica affects neurotransmitters like GABA in the brain, and the nervous system needs time to readjust as the medication is reduced, which is why gradual tapering is essential for a safe transition off the medication, as noted in studies on the efficacy of pregabalin in treating anxiety and epilepsy 3, 2, 4, 5.
- Some patients may require a slower taper over several months, especially those on higher doses or who have been taking Lyrica long-term, highlighting the importance of close medical supervision throughout the weaning process.