Tab Acuvin (Quinapril) Composition
Tab Acuvin contains quinapril hydrochloride as the active pharmaceutical ingredient, available in tablet strengths of 5 mg, 10 mg, 20 mg, or 40 mg of quinapril. 1
Active Ingredient
Quinapril hydrochloride is the hydrochloride salt of quinapril, which is the ethyl ester of quinaprilat, a non-sulfhydryl angiotensin-converting enzyme (ACE) inhibitor 1
The chemical name is [3S-[2[R*(R*)], 3R*]]-2-[2-[[1-(ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid, monohydrochloride 1
The empirical formula is C25H30N2O5 •HCl 1
Quinapril hydrochloride appears as a white to off-white amorphous powder that is freely soluble in aqueous solvents 1
Inactive Ingredients (Excipients)
Each tablet contains the following inactive ingredients 1:
- Binding agents: Crospovidone, povidone
- Filler: Lactose monohydrate
- Alkalizing agent: Magnesium carbonate
- Lubricant: Magnesium stearate
- Coloring agents: Iron oxide red, iron oxide black, titanium dioxide
- Coating materials: Talc, polyvinyl alcohol, polyethylene glycol
Pharmacological Mechanism
Quinapril is a prodrug that undergoes rapid hepatic de-esterification after absorption to form quinaprilat, the active diacid metabolite that potently inhibits ACE 2, 3
On a weight basis, quinaprilat is three times as potent an ACE inhibitor as quinapril itself 2
Approximately 60% of an oral dose of quinapril is absorbed, and absorption is unaffected by food (unlike captopril) 2
Peak serum concentrations of quinapril and quinaprilat are achieved within one and two hours, respectively 2
Quinaprilat has strong binding capacity to tissue ACE, allowing for once-daily dosing 2