What are the causes of scattered ulcers in the vaginal introitus?

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Last updated: April 14, 2025View editorial policy

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Differential Diagnosis for Scattered Ulcers in the Vaginal Opening

  • Single Most Likely Diagnosis
    • Genital herpes: This is a common sexually transmitted infection caused by the herpes simplex virus, characterized by painful ulcers in the genital area, including the vaginal opening. The scattered nature of the ulcers and their location at the vaginal opening make genital herpes a prime consideration.
  • Other Likely Diagnoses
    • Syphilis: The primary stage of syphilis can present with a single ulcer (chancre) but in some cases, especially if untreated, it can progress to multiple ulcers. The location can be anywhere on the genitals, including the vaginal opening.
    • Chancroid: Caused by Haemophilus ducreyi, chancroid is characterized by one or more painful ulcers or sores on the genitals. It's less common in developed countries but should be considered, especially in travelers or individuals with multiple sexual partners.
    • Lichen planus: This is an inflammatory condition that can affect the skin and mucous membranes, including the vagina. It can cause ulcers, but they are typically accompanied by other symptoms like itching and white patches.
  • Do Not Miss Diagnoses
    • Cancer (e.g., vulvar cancer): Although rare, any ulceration in the genital area that does not heal should prompt an investigation for cancer. Vulvar cancer can present with ulcers, and early detection is crucial for treatment outcomes.
    • HIV/AIDS: Individuals with HIV/AIDS are more susceptible to a variety of infections, including those that cause ulcers (like herpes simplex). The presence of scattered ulcers could indicate an immune-compromised state.
  • Rare Diagnoses
    • Behçet's disease: A rare disorder that causes blood vessel inflammation throughout the body, leading to symptoms like mouth sores, genital sores, skin rashes, and eye inflammation. The genital ulcers can resemble those seen in other conditions but are part of a broader systemic disease.
    • Aphthous ulcers: More commonly known as canker sores when they occur in the mouth, these ulcers can rarely occur on the genitals, including the vaginal opening. They are typically benign and self-limiting but can be painful.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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