From the Research
Berberine, in particular, has been associated with liver injury, especially at high doses or with prolonged use, and thus warrants caution 1. Several of the supplements you listed have potential liver concerns that warrant caution.
- Berberine has been associated with rare cases of liver injury, particularly at high doses or with prolonged use, as it inhibits hepatic gluconeogenesis, increases glycolysis, and impairs mitochondrial function, which can lead to a narrow margin between benefits and toxicity 1.
- While generally considered safe, Bergamot Orange Extract contains compounds similar to those in grapefruit that may affect liver enzyme activity and drug metabolism.
- Fucus vesiculosus (bladderwrack) seaweed extract contains iodine which, in excess, could potentially stress liver function in sensitive individuals. The other supplements—Nuchido Time, Alpha-Lipoic Acid (ALA), Nitric Oxide supplements, Glyco-Gen, Chondroitin Sulfate Sodium, and Chicken Comb Extract—have not shown significant direct liver toxicity in typical supplemental doses, though ALA has rare reports of liver reactions at high doses 2. If you have existing liver disease, are taking medications metabolized by the liver, or plan to use these supplements long-term, consult with a healthcare provider before starting them, as the liver processes most supplements, and combining multiple products increases the overall burden on liver function 3. Start with lower doses, monitor for symptoms like fatigue, abdominal pain, or yellowing skin, and consider periodic liver function tests if using these supplements regularly, especially in combination. Recent studies have also highlighted the importance of understanding the molecular mechanisms of liver diseases and the potential role of phytochemicals like berberine in their treatment, emphasizing the need for careful consideration of the benefits and risks of these supplements 2, 4.