What are the treatment options for patients with elevated Low-Density Lipoprotein (LDL) cholesterol who are unresponsive to statins or other lipid-lowering therapies, including those with familial hypercholesterolemia, considering Proprotein Convertase Subtilisin/Kexin Type 9 inhibitors (PCSK9i)?

Medical Advisory BoardAll articles are reviewed for accuracy by our Medical Advisory Board

Educational purpose only • Exercise caution as content is pending human review

Article Review Status

Submitted

Under Review

Approved

Last updated: January 19, 2026 • View editorial policy

Personalize

Help us tailor your experience

Which best describes you? Your choice helps us use language that's most understandable for you.

Related Questions

What is the recommended treatment for patients with elevated Low-Density Lipoprotein (LDL) cholesterol levels using Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) inhibitors?

What are the treatment options for patients requiring significant Low-Density Lipoprotein (LDL) cholesterol reduction, particularly those at high risk of cardiovascular events, using Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) inhibitors?

In an adult with established atherosclerotic cardiovascular disease or low‑density lipoprotein cholesterol ≥70 mg/dL and a 10‑year atherosclerotic cardiovascular disease risk ≥7.5%, what is the guideline‑recommended lipid‑lowering regimen, including the use of proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors (evolocumab, alirocumab) per the CLEAR Outcomes trial and alternatives for statin intolerance?

Does Repatha (evolocumab) help with hypertriglyceridemia?

What is the recommended PSK9 (Proprotein Convertase Subtilisin/Kexin Type 9) inhibitor and dosing regimen for reducing LDL (Low-Density Lipoprotein) cholesterol levels?

What are the uses of Acetylcysteine (N-acetylcysteine) effervescent tablets?

What is the typical recovery time for a muscular strain in a healthy adult with no significant past medical history?

How to switch an adult patient with type 2 diabetes from Novo Mix (insulin aspart protamine/insulin aspart) to insulin aspart and insulin glargine as an inpatient?

How do PCSK9 (Proprotein Convertase Subtilisin/Kexin Type 9) inhibitors affect kidney function in patients with pre-existing kidney disease?

What is causing muscle spasms in the neck and leg of a patient after undergoing dialysis?

What are the potential nail disorders associated with isotretinoin (13-cis-retinoic acid) treatment and how can they be managed?

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

Have a follow-up question?

Our Medical A.I. is used by practicing medical doctors at top research institutions around the world. Ask any follow up question and get world-class guideline-backed answers instantly.