From the FDA Drug Label
- 1 Schizophrenia Adults The recommended starting and target dose for aripiprazole tablets is 10 or 15 mg/day administered on a once-a-day schedule without regard to meals Aripiprazole tablets have been systematically evaluated and shown to be effective in a dose range of 10 to 30 mg/day, when administered as the tablet formulation; however, doses higher than 10 or 15 mg/day were not more effective than 10 or 15 mg/day. Aripiprazole was studied in adolescent patients 13 to 17 years of age with schizophrenia at daily doses of 10 mg and 30 mg
The maximum daily dose of Abilify (Aripiprazole) is 30 mg/day as it has been studied in adolescent patients at this dose and has been shown to be effective in a dose range of 10 to 30 mg/day in adults 1.
From the Research
Maximum Daily Dose of Abilify (Aripiprazole)
The maximum daily dose of Abilify (Aripiprazole) is a crucial aspect of its administration. According to the available evidence:
- The recommended starting and target dose for aripiprazole is 10 or 15 mg/day administered on a once-a-day schedule without regard to meals 2.
- Aripiprazole has been systematically evaluated and shown to be effective in a dose range of 10 to 30 mg/day 2.
- Dosage increases should not be made before 2 weeks of continuous therapy, the time needed to achieve steady state 2.
- Results of five fixed-dose studies suggest that the threshold for clinical effect is between 5 and 10 mg/day, and the highest response rate is seen at 10 mg/day 3.
- Doses above 20 mg/day do not appear to provide any additional benefit and may be associated with a smaller change in symptom scores 3.
- A literature review reveals an effective dose range between 10 and 25 mg/day for aripiprazole in schizophrenia, with less than 10 mg/day not showing significant efficacy on symptoms of schizophrenia, apart from a specific short-term effect on agitation, at very low doses (starting at 1mg) 4.
- Optimization of treatment, at doses above 25 mg/day, cannot be the subject of evidence-based recommendations 4.
Key Findings
- The effective dose range for aripiprazole is between 10 and 30 mg/day 2, 4.
- The optimal dose for aripiprazole is 10 mg/day, with doses above 20 mg/day providing no additional benefit 3.
- Aripiprazole is generally well tolerated, with common adverse effects including headache, anxiety, insomnia, nausea, vomiting, and lightheadedness 5, 6.