What is the diagnosis for a 69-year-old male presenting with a pruritic (itchy) rash on the upper legs, worsening over 5 days, accompanied by a sensation of crawling skin (formication), which began while staying at a hotel during travel?

Medical Advisory BoardAll articles are reviewed for accuracy by our Medical Advisory Board
Educational purpose only • Exercise caution as content is pending human review
Article Review Status
Submitted
Under Review
Approved

Last updated: April 14, 2025View editorial policy

Personalize

Help us tailor your experience

Which best describes you? Your choice helps us use language that's most understandable for you.

Differential Diagnosis for Itchy Rash

  • Single most likely diagnosis
    • Scabies: The patient's symptoms of an itchy rash, worsening itching, and a sensation of "critters" crawling on him, especially after staying in a hotel, are highly suggestive of scabies. Scabies is a contagious skin infestation caused by the mite Sarcoptes scabiei, often acquired through direct skin-to-skin contact or by sharing personal items, which could have been contaminated in the hotel.
  • Other Likely diagnoses
    • Bed bugs: Given the patient's recent travel and hotel stay, bed bug bites are a plausible cause for the itchy rash. Bed bugs can cause significant discomfort and their bites often result in itchy, red welts.
    • Contact dermatitis: This could be a reaction to new soaps, laundry detergents, or other products used during travel, leading to an itchy rash.
    • Flea bites: If the hotel room had fleas, either from previous pets or infestation, this could cause an itchy rash.
  • Do Not Miss (ddxs that may not be likely, but would be deadly if missed.)
    • Neurological disorders (e.g., neuropathy, delusional parasitosis): Although less likely, conditions that affect the nervous system can cause sensations of itching or crawling without an actual skin infestation. Delusional parasitosis is a psychiatric condition where the patient has a fixed, false belief of being infested with parasites, which is crucial to differentiate from actual infestations.
  • Rare diagnoses
    • Ectoparasitic infestations other than scabies or bed bugs (e.g., lice, ticks): While less common, other ectoparasites could potentially cause similar symptoms.
    • Allergic reactions to medications: If the patient started any new medications during travel, an allergic reaction could manifest as an itchy rash.
    • Systemic conditions with skin manifestations (e.g., renal or liver disease): Certain systemic diseases can cause pruritus (itching) without a clear rash, though this would be less likely given the acute onset and description of a rash.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

Have a follow-up question?

Our Medical A.I. is used by practicing medical doctors at top research institutions around the world. Ask any follow up question and get world-class guideline-backed answers instantly.