From the Guidelines
Fluvoxamine can potentially cause several nutritional deficiencies, including hyponatremia, reduced vitamin B12 and folate levels, and decreased overall nutrient intake due to its effects on appetite and gastrointestinal function. The medication's impact on antidiuretic hormone regulation can lead to hyponatremia, a condition characterized by low sodium levels in the blood 1. Additionally, fluvoxamine may cause gastrointestinal side effects such as nausea, vomiting, and diarrhea, which can impair nutrient absorption and lead to deficiencies over time. Some patients taking fluvoxamine may also experience reduced appetite, resulting in decreased overall nutrient intake. Furthermore, SSRIs like fluvoxamine can interfere with the absorption of essential nutrients, including vitamin B12 and folate. To manage these potential deficiencies, patients should maintain adequate hydration, eat a balanced diet rich in essential nutrients, and consider regular monitoring of electrolyte levels, particularly sodium. In cases of significant appetite reduction or persistent gastrointestinal symptoms, a multivitamin supplement may be beneficial. Key considerations for patients taking fluvoxamine include:
- Maintaining adequate hydration to prevent hyponatremia
- Eating a balanced diet rich in essential nutrients
- Regular monitoring of electrolyte levels, particularly sodium
- Considering a multivitamin supplement in cases of significant appetite reduction or persistent gastrointestinal symptoms
- Being aware of the potential for reduced vitamin B12 and folate levels and discussing this with their healthcare provider if concerned.
From the Research
Nutritional Deficiencies Associated with Fluvoxamine
There is no direct information available in the provided study about nutritional deficiencies associated with fluvoxamine.
- The study 2 focuses on the use of fluvoxamine in the management of adults with anxiety disorders, its efficacy, and tolerability profile.
- It discusses the drug's mechanism of action, its effects on various anxiety disorders, and compares it with other SSRIs and tricyclic antidepressants.
- However, it does not mention any nutritional deficiencies that may be associated with fluvoxamine use.
Adverse Events
- The study 2 reports that fluvoxamine is generally well tolerated, with nausea being the most common adverse event.
- Other less common adverse events include somnolence, asthenia, headache, dry mouth, and insomnia.
- There is no mention of nutritional deficiencies as a potential adverse event associated with fluvoxamine use.