What are the current indications for prescribing injectable testosterone (testosterone) to women?

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Last updated: February 14, 2025View editorial policy

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From the Research

Current Indications for Prescribing Injectable Testosterone to Women

The current indications for prescribing injectable testosterone to women are limited and guided by specific clinical guidelines.

  • Loss of sexual desire with associated personal distress is currently the only agreed-on indication for judicious testosterone supplementation for postmenopausal women 1.
  • The National Institute for Health and Care Excellence guideline recommends considering testosterone supplementation for women with low sexual desire if hormone replacement therapy (HRT) alone has been ineffective 2.
  • Testosterone supplementation can be considered for menopausal women with low sexual desire if hormone replacement therapy alone is not effective, as stated in the NICE Guidelines published in 2015 3.

Safety and Prescribing Practices

There is concern that testosterone is being prescribed without proper diagnostic evaluation and for unproven medical conditions 4.

  • The physiology of testosterone as a normal female hormone is poorly understood, leading to unregulated and dangerous prescribing practices by physicians and other health care professionals 5.
  • There is a need for more research and safer, regulated products to prescribe, as well as a greater understanding of the potential provider-level and system-level factors that contribute to current prescribing practices 4.

References

Research

Use of Testosterone in Postmenopausal Women.

Endocrinology and metabolism clinics of North America, 2021

Research

Testosterone therapy for menopausal women.

Drug and therapeutics bulletin, 2017

Research

Patterns of testosterone prescription overuse.

Current opinion in endocrinology, diabetes, and obesity, 2017

Research

Testosterone Therapy in Women: A Clinical Challenge.

Obstetrics and gynecology, 2021

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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