From the Research
VELASOF/SOVIHEP V (sofosbuvir/velpatasvir) and perinorm (metoclopramide) can be used together, but with caution and monitoring, as metoclopramide may reduce the absorption of sofosbuvir/velpatasvir, potentially decreasing its effectiveness in treating hepatitis C. The primary concern is maintaining adequate blood levels of the antiviral medication to ensure successful treatment of hepatitis C 1. To minimize potential interactions, it is recommended to separate the administration of these medications by at least 2 hours, with sofosbuvir/velpatasvir taken with food to optimize absorption, and metoclopramide taken 30 minutes before meals. Patients should be monitored for any changes in the effectiveness of the hepatitis C treatment or increased side effects, and dosing adjustments or alternative medications may be necessary if symptoms of decreased efficacy occur, such as viral load not decreasing as expected 2. Always inform all healthcare providers about all medications being taken to prevent potential interactions, and use drug interaction software and collaboration with pharmacists to optimize drug safety 1. Key considerations include:
- Separating administration of sofosbuvir/velpatasvir and metoclopramide by at least 2 hours
- Taking sofosbuvir/velpatasvir with food to optimize absorption
- Monitoring for changes in treatment effectiveness or side effects
- Informing all healthcare providers about all medications being taken
- Using drug interaction software and collaborating with pharmacists to optimize drug safety 3, 1.