From the Research
There is no known significant drug interaction between Velasof/Sovihep V (sofosbuvir/velpatasvir) and Coenzyme Q10 (CoQ10), and patients can generally take CoQ10 supplements while on sofosbuvir/velpatasvir therapy for hepatitis C without concern for interference with treatment efficacy. Sofosbuvir/velpatasvir is primarily metabolized by the liver through pathways that don't substantially overlap with CoQ10 metabolism 1. CoQ10 is a naturally occurring antioxidant that some patients take as a supplement for various health benefits, including supporting heart health and reducing statin-related muscle pain.
While on hepatitis C treatment, it's always advisable to inform your healthcare provider about all supplements you're taking, including CoQ10. If you experience any unusual symptoms while taking both, contact your healthcare provider. The standard course of sofosbuvir/velpatasvir is typically 12 weeks, and maintaining good adherence to this medication regimen is essential for successful hepatitis C treatment, regardless of supplement use. According to the most recent study, sofosbuvir plus velpatasvir for 8 weeks in patients with acute hepatitis C has shown high efficacy and safety, with all patients who completed therapy and were followed-up achieving sustained virologic response 1.
Key points to consider:
- No significant drug interaction between sofosbuvir/velpatasvir and CoQ10
- CoQ10 can be taken as a supplement while on sofosbuvir/velpatasvir therapy
- Inform your healthcare provider about all supplements, including CoQ10
- Maintain good adherence to the sofosbuvir/velpatasvir medication regimen for successful hepatitis C treatment.