From the Research
Coricidin and Tessalon should not be taken together without medical supervision due to potential drug interactions, as evidenced by the risks of increased drowsiness, excessive respiratory depression, or other adverse effects 1, 2, 3.
Key Considerations
- Coricidin is a brand name for cold and flu medications containing chlorpheniramine (an antihistamine) and often dextromethorphan (a cough suppressant), while Tessalon (benzonatate) is a prescription cough suppressant that works by numbing stretch receptors in the lungs.
- Using these medications together could potentially cause increased drowsiness, excessive respiratory depression, or other adverse effects, as seen in cases of Coricidin abuse 1, 2, 3.
- A recent study on the efficacy of a combination syrup containing bilastine, dextromethorphan, and phenylephrine for cough relief in patients with a common cold or allergy showed promising results, with significant improvements in cough severity and minimal adverse effects 4.
Recommendations
- If you're experiencing a cough severe enough to consider multiple medications, it's best to consult with a healthcare provider first.
- They can recommend an appropriate treatment plan based on your specific symptoms and medical history.
- For cough management, it's generally advisable to try one medication at a time rather than combining multiple products with similar effects.
- If one medication isn't providing relief, speak with your doctor about alternatives rather than adding another medication on your own.
Important Findings
- A study on trends in adolescent suicidal and recreational ingestions of over-the-counter Coricidin preparations found a significant increase in ingestions over a 14-year period, with tachycardia being the most common clinical effect 1.
- Another study reported severe manifestations of Coricidin intoxication, including prolonged anticholinergic complications and significant acetaminophen-induced hepatotoxicity 3.