From the Guidelines
Histamine can contribute to constipation in some individuals, particularly those with histamine intolerance or mast cell disorders, and addressing this issue requires a comprehensive approach that prioritizes dietary modifications, targeted supplements, and evidence-based treatments. To manage histamine-related constipation, it is essential to reduce high-histamine foods like fermented products, aged cheeses, processed meats, and leftover foods, and instead focus on fresh, low-histamine options like freshly cooked meats, fresh vegetables, and non-citrus fruits 1.
Some key considerations for managing constipation include:
- Ensuring adequate intake of fibre and fluid, as recommended in the management of adult patients with severe chronic small intestinal dysmotility 1
- Using bulk forming laxatives such as unprocessed wheat bran, methylcellulose, ispaghula, and sterculia, which are effective in managing constipation 1
- Considering the use of osmotic laxatives like macrogols, lactulose, or magnesium salts, which increase the amount of water in the large bowel and can help relieve constipation 1
- Adding stimulant laxatives if there is an inadequate response to an osmotic laxative, but avoiding their excessive use to prevent diarrhoea and hypokalaemia 1
In terms of targeted supplements, consider taking a DAO (diamine oxidase) enzyme supplement before meals containing histamine, typically 1-2 capsules (10,000-20,000 HDU), as well as quercetin (500-1000mg daily in divided doses) to help stabilize mast cells that release histamine. For immediate constipation relief, magnesium citrate (300-400mg before bed) can be effective while addressing the underlying histamine issues, and vitamin C (500-1000mg daily) may help with both histamine degradation and bowel motility.
It is crucial to note that the relationship between histamine and constipation is complex, and some people may experience paradoxical reactions where histamine causes constipation rather than the diarrhea more commonly associated with histamine reactions. Therefore, a personalized approach that takes into account individual circumstances and medical history is essential for effective management.
From the Research
Histamine and Constipation
- There is no direct evidence in the provided studies that links histamine to constipation 2, 3, 4, 5, 6.
- The studies focus on the diagnosis, management, and treatment of constipation, including lifestyle changes, fiber supplementation, and pharmacologic therapies 2, 3, 4, 5, 6.
- Fiber supplementation is shown to be effective in improving constipation symptoms, with psyllium and pectin having significant effects 4, 5.
- The optimal type and regime of fiber supplementation, including dose and treatment duration, are discussed in the studies 4, 5.
- However, none of the studies mention histamine as a factor in constipation, and therefore, there is no evidence to support a link between the two 2, 3, 4, 5, 6.