From the Research
Wellbutrin (bupropion) and buspirone can be safely taken together as they work through different mechanisms and are often prescribed as a combination therapy for certain mental health conditions. Wellbutrin primarily affects dopamine and norepinephrine levels and is used to treat depression and aid in smoking cessation, while buspirone affects serotonin receptors and is primarily used for anxiety disorders. The standard dosing for Wellbutrin ranges from 150-450 mg daily (often divided into doses), while buspirone is typically taken at 15-30 mg daily (divided into 2-3 doses). When starting this combination, it's best to begin with lower doses and gradually increase as tolerated to minimize side effects. Potential side effects when taking both medications may include headache, nausea, dizziness, insomnia, and dry mouth. This combination can be particularly helpful for patients who have both depression and anxiety symptoms, as Wellbutrin addresses the depression while buspirone targets anxiety without the sedation or dependence risks associated with benzodiazepines. Always take these medications as prescribed and report any concerning side effects to your healthcare provider.
Key Considerations
- The most recent study 1 found that bupropion does not increase anxiety when compared to selective serotonin reuptake inhibitors (SSRIs) over a 12-week period.
- A systematic review and meta-analysis 2 supports the use of bupropion as a sole or coprescribed antidepressant, particularly if weight gain or sexual dysfunction are concerns.
- Buspirone's mechanism of action is complex, but it primarily affects 5-HT1A receptors, and its use is indicated in the treatment of generalized anxiety disorders 3.
- When combining bupropion with other medications, such as SSRIs or SNRIs, it is generally well tolerated and can boost antidepressant response, as well as reduce SSRI or SNRI-associated sexual side effects 4.