Differential Diagnosis for New Small Soft Bump over Jugular Vein on Immunotherapy, Endometrial Cancer
- Single Most Likely Diagnosis
- Metastatic disease (e.g., lymph node metastasis from endometrial cancer): This is a likely diagnosis given the patient's history of endometrial cancer and the location of the bump over the jugular vein, which could indicate lymphatic spread.
- Other Likely Diagnoses
- Injection site reaction or lipoma: Given the patient is on immunotherapy, an injection site reaction could occur, although this is less likely if the bump is specifically over the jugular vein. A lipoma, although common, might not typically present in this specific location without a history of trauma or other predisposing factors.
- Thrombophlebitis or superficial thrombosis: Immunotherapy and cancer can increase the risk of thrombotic events. A bump over the jugular vein could potentially be related to a thrombotic process, especially if the patient has risk factors for thrombosis.
- Do Not Miss Diagnoses
- Jugular vein thrombosis: This is a critical diagnosis to consider because it can lead to serious complications, including pulmonary embolism and sepsis, especially in the context of immunotherapy and cancer.
- Lymphoma or other secondary malignancies: Although less common, the development of a new lymphoma or other secondary malignancy in the setting of immunotherapy for endometrial cancer is a possibility that should not be overlooked.
- Rare Diagnoses
- Kaposi's sarcoma: This is a rare tumor that can occur in the setting of immunosuppression and could potentially present as a soft bump, although it is more commonly associated with skin lesions.
- Amyloidosis: In rare cases, amyloid deposits can accumulate in soft tissues and present as bumps, but this would be an unusual presentation and location for amyloidosis.