From the Research
The maximum recommended dose of Rupall (rupatadine) for adults and adolescents 12 years and older is 10 mg once daily, as exceeding this dose can increase the risk of side effects without providing additional therapeutic benefit, as suggested by general principles of pharmacology and toxicology 1. For children aged 2-11 years, the maximum dose is typically determined based on weight, with 2.5 mg recommended for those weighing 10-25 kg and 5 mg for those weighing more than 25 kg, once daily. Rupall should be taken with or without food, and the tablet should be swallowed whole. Dose adjustments are necessary for patients with moderate to severe renal or hepatic impairment, where the recommended dose is often reduced to minimize potential adverse effects, such as 10 mg every other day, although specific guidance may vary based on the patient's condition and the prescribing information available 2. The medication works by blocking histamine H1 receptors and platelet-activating factor (PAF), which helps relieve allergy symptoms like sneezing, itching, and nasal congestion. Key considerations in determining the maximum effective dose include the balance between efficacy and safety, with the goal of achieving the best possible outcome for the patient while minimizing the risk of adverse effects, as discussed in the context of drug development and pharmacological treatment 3. In clinical practice, the selection of the maximum tolerated dose or the maximum effective dose should be guided by the most recent and highest quality evidence available, taking into account factors such as the patient's age, weight, renal and hepatic function, and the specific clinical indication being treated, as well as general principles of pharmacology and toxicology 4, 5.