What is the cause of a dry rash in the axillary (armpit) region?

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Last updated: April 15, 2025View editorial policy

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Differential Diagnosis for Dry Rash in Axilla

  • Single most likely diagnosis
    • Contact dermatitis: This is a common condition that occurs when the skin comes into contact with an irritant or allergen, leading to a dry rash. The axilla is a frequent site for contact dermatitis due to friction, sweat, and potential allergens in antiperspirants or clothing.
  • Other Likely diagnoses
    • Eczema (atopic dermatitis): A chronic skin condition characterized by dry, itchy, and inflamed skin. The axilla can be an affected area, especially in individuals with a history of atopic dermatitis.
    • Intertrigo: A skin condition caused by friction and moisture in skin folds, leading to a rash. The axilla is a common site for intertrigo, especially in warm weather or in individuals who are overweight.
    • Seborrheic dermatitis: A condition causing scaly patches, red skin, and stubborn dandruff, often affecting oily areas of the body like the axilla.
  • Do Not Miss (ddxs that may not be likely, but would be deadly if missed.)
    • Lymphoma (cutaneous T-cell lymphoma): Although rare, cutaneous T-cell lymphoma can present with skin lesions or rashes in unusual locations, including the axilla. Early diagnosis is crucial for effective treatment.
    • Invasive fungal infections: In immunocompromised individuals, fungal infections like histoplasmosis or cryptococcosis can cause skin lesions. These conditions are life-threatening and require prompt diagnosis and treatment.
  • Rare diagnoses
    • Pityriasis rosea: A skin condition characterized by a rash that can appear in the axilla, although it more commonly affects the trunk.
    • Psoriasis: An autoimmune condition that can cause dry, scaly patches on the skin, including in the axilla, though it's less common in this area compared to elbows, knees, or scalp.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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