SLU-PP-332 Safety for Human Ingestion
SLU-PP-332 is NOT approved or safe for human ingestion and should only be used as a research chemical tool in laboratory settings. There are no clinical trials, safety data, or regulatory approvals for human use of this compound.
Current Status and Evidence
Research-Only Compound
- SLU-PP-332 is a synthetic estrogen receptor-related receptor (ERR) pan-agonist that has been studied exclusively in preclinical animal models and cell culture systems 1, 2.
- The compound was developed as a chemical tool to study ERR biology and exercise mimetic effects in mice, not as a therapeutic agent for human use 2.
- All published studies describe intraperitoneal (injection) administration in mice, not oral human consumption 1, 2, 3, 4.
Lack of Human Safety Data
- There are no published human clinical trials, pharmacokinetic studies, toxicology assessments, or safety profiles for SLU-PP-332 in humans 1, 2, 3, 4.
- The compound lacks oral bioavailability, which led researchers to develop SLU-PP-915 as an orally bioavailable alternative for continued preclinical research 1.
- No regulatory agency (FDA, EMA, or equivalent) has reviewed or approved SLU-PP-332 for human use in any capacity 1, 2, 3, 4.
Preclinical Findings Only
- Studies demonstrate effects on mitochondrial function, exercise capacity, and metabolic parameters exclusively in mouse models of obesity, metabolic syndrome, and heart failure 2, 3, 4.
- While these preclinical results show promise for potential therapeutic development, they represent early-stage research that is years away from human application 3, 4.
Critical Safety Concerns
Unknown Human Toxicity Profile
- The compound's safety, appropriate dosing, drug interactions, contraindications, and adverse effects in humans are completely unknown 1, 2.
- Sulfonic acid esters (structural components related to the compound class) have demonstrated genotoxic potential in bacterial and mammalian cell systems, though this specific compound has not been evaluated for such effects 5.
No Quality Control for Human Use
- Research-grade chemicals are not manufactured under Good Manufacturing Practice (GMP) standards required for human consumption 1, 2.
- Purity, contaminants, and stability profiles suitable for human ingestion have not been established 1, 2.
Bottom Line
SLU-PP-332 remains an experimental research tool with no established safety profile, regulatory approval, or appropriate formulation for human consumption. Any use outside of controlled laboratory research settings would be dangerous and medically inappropriate 1, 2, 3, 4.