What supplements and vitamins are recommended after hip replacement surgery?

Supplements and Vitamins After Hip Replacement

All patients undergoing hip replacement surgery should receive oral nutritional supplements (ONS) postoperatively, combined with calcium (1,000-1,200 mg/day) and vitamin D (600-800 IU/day) supplementation, to reduce complications and support recovery. 1, 2

Core Nutritional Supplementation Strategy

Standard Oral Nutritional Supplements (ONS)

• Start ONS within the first postoperative week and continue for 1-6 months to significantly increase energy and nutrient intake while reducing postoperative complications by approximately 29% (RR 0.71). 1
• Standard ONS formulations are recommended over high-protein versions, as current evidence shows no additional benefit from specialized high-protein supplements for reducing complications. 1
• ONS should be offered to all hip replacement patients regardless of baseline nutritional status. 1

Essential Vitamin and Mineral Supplementation

Calcium and Vitamin D (Mandatory)

• Provide 1,000-1,200 mg elemental calcium daily through diet and supplements combined. 2, 3
• Provide 600-800 IU vitamin D daily as a minimum, with higher doses often needed to maintain serum 25(OH)D levels ≥30 ng/mL. 2, 3
• These supplements support bone healing, reduce bone mineral density loss, and are particularly critical in elderly patients. 1

Complete Vitamin and Trace Element Coverage

• If oral intake remains insufficient to meet 70% of daily requirements despite ONS, provide a full range of vitamins and trace elements daily. 1, 2
• Well-nourished patients who resume adequate oral nutrition by postoperative day 5 may not require additional vitamin/trace element supplementation. 1

Protein and Energy Requirements

Protein Targets

• Aim for 1.5 g/kg ideal body weight daily (approximately 20% of total energy) to limit nitrogen losses and support tissue repair. 1, 2
• Include high-quality protein sources at each meal to stimulate muscle protein synthesis. 2
• Consider protein-enriched meals and additional protein drinks if oral intake is insufficient. 2

Energy Targets

• Target 25-30 kcal/kg ideal body weight daily, with requirements approaching 30 kcal/kg under severe stress conditions. 1, 2
• Distribute calories as approximately 20% protein, 30% fat, and 50% carbohydrates. 1, 2

Timing and Duration

Immediate Postoperative Period

• Resume oral feeding as early as possible, ideally within 4 hours post-procedure, to minimize catabolism. 2
• Begin with clear liquids and progress rapidly to full diet as tolerated. 2
• Ensure adequate hydration with at least 2L of fluid daily. 2

Continuation of Support

• Continue nutritional supplementation until adequate oral intake is established and nutritional status stabilizes. 2
• Most studies used ONS for 1-6 months postoperatively. 1

Special Considerations for High-Risk Patients

Malnourished or Sarcopenic Patients

• Patients with sarcopenia or undernutrition show greater vulnerability to surgery with more pronounced drops in hemoglobin (-2.37 g/dL) and blunted stress responses. 4
• These patients require more intensive and longer duration nutritional therapy. 2, 4
• Consider combining nutritional support with resistance exercise to enhance recovery. 2

Elderly Patients

• Nutritional interventions must be part of an individually tailored, multidimensional, multidisciplinary team approach. 1, 2
• Combine nutritional support with early mobilization and physical rehabilitation to maximize muscle strength and functional recovery. 2
• Elderly patients react more sensitively to food deprivation than younger patients. 1

Advanced Nutritional Support (When Standard Measures Fail)

Parenteral Nutrition Consideration

• If oral and enteral intake remain impossible for >3 days or <50% of requirements for >1 week, consider 3 days of perioperative peripheral parenteral nutrition (PN) followed by ONS. 1
• This combined approach reduces complications (RR 0.21) but does not affect mortality or length of stay. 1
• PN carries risks and should only be used when enteral routes are inadequate. 1

What NOT to Do

• Do not use supplementary overnight tube feeding unless there is a separate indication for enteral nutrition, as it is poorly tolerated without clear benefits. 1

Monitoring and Adjustment

Assessment Parameters

• Regularly assess weight, muscle mass, and functional capacity to evaluate response to nutritional therapy. 2
• Monitor serum albumin, prealbumin, and hemoglobin levels. 5
• Track actual dietary intake daily to ensure requirements are being met. 6

Common Pitfalls to Avoid

• Do not prolong preoperative fasting, which worsens catabolism and delays recovery. 2
• Do not rely solely on BMI for nutritional assessment, as it may underestimate malnutrition. 2
• Do not neglect physical rehabilitation alongside nutritional support. 2
• Do not unnecessarily restrict diet beyond 24 hours after surgery. 2
• Most patients fail to meet reference energy and protein needs through diet alone in the first 10 postoperative days, making supplementation essential. 4

Evidence Quality Note

The evidence supporting ONS comes from a high-quality Cochrane review of 41 trials involving 3,881 hip fracture patients, though individual trial quality was low to very low. 1 Despite methodological limitations, the consistent finding of reduced complications with standard ONS, combined with low adverse event rates, supports strong recommendation for routine use. 1