From the Research
The most effective treatment for hypertension, based on the latest evidence, is a fixed combination of an ACE inhibitor and a calcium channel blocker, such as ramipril and amlodipine, as recommended by the 2018 ESH/ESC guidelines 1. This combination has been shown to be superior to other combinations, such as beta-blocker/diuretic associations, in preventing myocardial infarction and total mortality, and has been demonstrated to be effective in reducing cardiovascular events in patients with hypertension. The use of a fixed combination of an ACE inhibitor and a calcium channel blocker has several advantages, including increased compliance with treatment, reduced risk of adverse effects, and improved control of hypertension. Some studies have also shown that the combination of an ACE inhibitor and a calcium channel blocker is effective in reducing the risk of cardiovascular events, such as myocardial infarction and stroke, and is well-tolerated by patients 2. In addition, the combination of ramipril and amlodipine has been shown to be effective in reducing blood pressure and improving cardiovascular outcomes in patients with hypertension, and is considered a first-line treatment option for patients with hypertension 1. It is also important to consider the harm-benefit balance of any treatment, and to evaluate the potential benefits and risks of each treatment option for each individual patient 3. Overall, the evidence suggests that a fixed combination of an ACE inhibitor and a calcium channel blocker, such as ramipril and amlodipine, is a effective and well-tolerated treatment option for patients with hypertension, and should be considered as a first-line treatment option.
Key points to consider when treating hypertension include:
- The use of a fixed combination of an ACE inhibitor and a calcium channel blocker, such as ramipril and amlodipine, as a first-line treatment option
- The importance of evaluating the harm-benefit balance of each treatment option for each individual patient
- The need to consider the potential benefits and risks of each treatment option, including the risk of adverse effects and the potential for improved cardiovascular outcomes
- The importance of regular monitoring of blood pressure and cardiovascular outcomes in patients with hypertension
- The potential benefits of using a fixed combination of an ACE inhibitor and a calcium channel blocker, including increased compliance with treatment and improved control of hypertension.