What is the cause of a spontaneous lump on the hand?

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Last updated: April 15, 2025 • View editorial policy

Differential Diagnosis for Spontaneous Bump on Hand

  • Single Most Likely Diagnosis + Ganglion cyst: This is the most common lump found on the hand, often appearing as a firm, rubbery bump, typically on the wrist. It is usually benign and can be caused by a herniation of a joint capsule or tendon sheath.
  • Other Likely Diagnoses + Lipoma: A benign tumor composed of fat tissue, which can appear as a soft, movable lump under the skin of the hand. + Epidermoid cyst: A benign cyst that can appear as a firm, lump under the skin, often filled with a cheesy material. + Abscess or boil: An infected sebaceous cyst or hair follicle that can cause a painful, swollen lump on the hand.
  • Do Not Miss Diagnoses + Osteosarcoma or other bone tumors: Although rare, these malignant tumors can present as a lump on the hand and are critical to diagnose early for effective treatment. + Infections like osteomyelitis or septic arthritis: These serious infections can cause swelling and a lump on the hand and require prompt medical attention to prevent serious complications. + Giant cell tumor of the tendon sheath: A rare, benign tumor that can cause a lump on the hand, but can be locally aggressive and cause significant symptoms.
  • Rare Diagnoses + Glomus tumor: A rare, benign tumor of the glomus body that can appear as a painful lump under the fingernail. + Enchondroma: A rare, benign cartilage tumor that can cause a lump on the hand, often associated with pain or fracture. + Soft tissue sarcomas: Rare, malignant tumors that can present as a lump on the hand, requiring early diagnosis and treatment for a favorable prognosis.

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This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.