What is the dose and frequency for Reglan (Metoclopramide)?

From the Guidelines

The dose and frequency for Reglan (Metoclopramide) is 5-20 mg tid-qid.

Details of Reglan Dosage

• The dosage of Metoclopramide can range from 5-20 mg and is typically administered three to four times a day (tid-qid) 1.
• It's worth noting that doses above 10 mg tid are not recommended due to the risk of QT prolongation 1.
• Metoclopramide is used to treat nausea and vomiting, as well as to accelerate gastric emptying, and is the only FDA-approved medication for gastroparesis 1.
• In the context of migraine treatment, Metoclopramide can be used as an adjunctive therapy to treat accompanying nausea and improve gastric motility, with a dosage of 10 mg IV or orally 20 to 30 minutes before or with a simple analgesic 1.

From the Research

Dose and Frequency of Reglan (Metoclopramide)

• The recommended dose and frequency of Reglan (Metoclopramide) vary depending on the condition being treated and the patient population 2, 3, 4.
• For oral preparations, the recommended duration of therapy is four to 12 weeks 2.
• Parenteral metoclopramide should be limited to one or two days of use 2.
• Regulatory authorities have issued restrictions on long-term use of metoclopramide at oral doses exceeding 10 mg 3-4 times daily due to the risk of tardive dyskinesia 3.
• Studies have used various dosing regimens, including:
  • 10 mg intravenously 4
  • 0.25 mg/kg intravenously in children 4
  • 15 mg controlled release twice daily 5
  • 10 mg or 20 mg domperidone three times daily (for comparison) 5
  • 10 mg every 6 hours as an intermittent infusion 6
  • 2 mg/h as a continuous infusion 6
• The choice of dose and frequency should be based on the individual patient's needs and medical condition, as well as consideration of potential adverse effects 2, 3, 4.