From the Guidelines
The typical dosage for Insulin 70/30, such as Novolin or Humulin, is administered before breakfast and before dinner.
Key Points
- The 70/30 insulin mix contains 70% NPH (neutral protamine Hagedorn) insulin and 30% regular insulin.
- Administration is usually before breakfast and before dinner 1.
- The exact dosage may vary depending on individual patient needs and blood glucose levels.
- Dose titration is important, and adjustments may be necessary based on blood glucose levels and the pharmacodynamic profile of each formulation 2, 1.
- Providers should consider regimen flexibility when devising a plan for the initiation and adjustment of insulin therapy for patients with type 2 diabetes 1.
- Studies have shown the noninferiority of basal insulin plus a single injection of rapid-acting insulin administered at the largest meal compared with basal insulin plus a GLP-1–receptor agonist or 2 daily injections of premixed insulins 1.
From the Research
Dosage for Insulin (Novolin or Humulin) 70/30
The dosage for Insulin (Novolin or Humulin) 70/30 can vary depending on the individual patient's needs and the specific treatment regimen.
- The typical administration frequency is twice daily, just before breakfast and dinner 3.
- However, some studies have shown that administering 70/30 biphasic insulin three times a day can be effective in maintaining glycemia in the target range and reducing the risk of hypoglycemia 4.
- The dosage can also be adjusted based on the patient's glucose levels, with some studies using an algorithm to determine the optimal dose 5.
- In some cases, once-daily injections of biphasic insulin aspart 70/30 or biphasic human insulin 70/30 in combination with metformin can be an effective treatment regimen for patients with type 2 diabetes 6.
Administration Timing
- The timing of insulin administration can also impact its effectiveness, with some studies showing that administering Humalog Mix25 just 5 minutes before meals can provide improved post-prandial glycemic control compared to administering Humulin 30/70 30 minutes before meals 7.
- However, the optimal administration timing may vary depending on the individual patient's needs and the specific insulin regimen being used.
Key Considerations
- The dosage and administration frequency of Insulin (Novolin or Humulin) 70/30 should be individualized based on the patient's specific needs and glucose levels 3, 4, 5, 6.
- Patients should work closely with their healthcare provider to determine the optimal treatment regimen and adjust the dosage as needed to achieve good glycemic control.