Cefdinir Dosing for a 100-Pound Pediatric Patient
For a 100-pound (45.5 kg) pediatric patient, administer cefdinir 300 mg every 12 hours (total 600 mg/day), which is the maximum daily dose for pediatric patients. 1
Weight-Based Calculation
- A 100-pound patient equals approximately 45.5 kg 1
- Standard pediatric dosing is 7 mg/kg every 12 hours or 14 mg/kg every 24 hours 2, 1
- Calculated dose would be 318.5 mg every 12 hours (7 mg/kg × 45.5 kg) 1
- However, the FDA label explicitly caps the maximum daily dose at 600 mg per day for all pediatric infections, regardless of weight 1
- Therefore, patients ≥43 kg (95 lbs) receive the maximum dose of 300 mg every 12 hours or 600 mg once daily 1
Dosing Regimen Options
Twice-daily dosing (preferred for most infections):
- 300 mg every 12 hours for 10 days 1
- This regimen is required for uncomplicated skin and skin structure infections 1
Once-daily dosing (acceptable for specific infections):
- 600 mg every 24 hours for 10 days 2, 1
- This option is effective for acute otitis media, sinusitis, and pharyngitis/tonsillitis 2, 1
- Once-daily dosing has not been studied in skin infections and should not be used for this indication 1
Clinical Context
- Cefdinir serves as an alternative agent for β-lactamase-producing Haemophilus influenzae in community-acquired pneumonia when amoxicillin-clavulanate cannot be used 3, 2
- The drug may be administered without regard to meals 1
- High-dose amoxicillin (90 mg/kg/day) remains superior for resistant pneumococcal infections 2
Important Caveat
Note the concentration discrepancy in your question: You mentioned "cefdinir 200mg/ml," but standard cefdinir oral suspension comes in 125 mg/5 mL or 250 mg/5 mL concentrations 1. A 200 mg/mL concentration does not exist in standard formulations and would represent an extremely concentrated preparation not commercially available 1.