What is the advantage of taking magnesium citrate over magnesium oxide in a patient taking Lasix (furosemide)?

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From the Research

Advantages of Magnesium Citrate over Magnesium Oxide

  • Magnesium citrate has higher solubility and bioavailability compared to magnesium oxide 1
  • Magnesium citrate increases urinary magnesium and citrate levels, while decreasing urinary oxalate levels when taken with meals 2
  • In patients taking furosemide, magnesium citrate supplementation can help correct magnesium deficiency and increase intracellular magnesium and serum potassium levels 3

Comparison of Magnesium Salts

  • Magnesium citrate is more soluble and bioavailable than magnesium oxide 1
  • Magnesium L-aspartate has better bioavailability compared to other stereoisomers of organic magnesium salts in correcting furosemide-induced magnesium deficiency 4
  • Sucrosomial magnesium has higher bioavailability compared to magnesium citrate, magnesium oxide, and magnesium bisglycinate 5

Relevance to Furosemide Treatment

  • Furosemide can cause magnesium depletion and hypomagnesemia in patients with congestive heart failure 3
  • Magnesium citrate supplementation can help mitigate this effect and provide cardioprotective effects 3

References

1
Research

Magnesium bioavailability from magnesium citrate and magnesium oxide.

Journal of the American College of Nutrition, 1990

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