What is Redensysl (dermal filler) and what are the considerations for its use in an adult patient seeking facial rejuvenation or skin revitalization?

Redensyl: Clarification and Dermal Filler Context

Redensyl is not a dermal filler—it is a topical cosmeceutical ingredient used in hair growth products. If you are asking about dermal fillers for facial rejuvenation, the evidence strongly supports hyaluronic acid (HA) fillers, particularly when combined with autologous platelet concentrates (PRP/PRF), as the gold standard approach for adult patients seeking facial rejuvenation and skin revitalization.

Optimal Dermal Filler Strategy for Facial Rejuvenation

First-Line Recommendation: HA + PRP Combination Therapy

For adult patients seeking facial rejuvenation, use a 50:50 mixture of non-crosslinked hyaluronic acid and platelet-rich plasma (PRP), which demonstrates superior outcomes compared to either treatment alone. 1

• This combination produces a 20%, 24%, and 17% increase in FACE-Q scores at 1,3, and 6 months post-treatment respectively, significantly outperforming PRP alone (9%, 11%, 8% improvement) or HA alone 2, 1
• The synergistic effect results in highly significant improvement in overall facial appearance (p<0.0001) and skin elasticity compared to monotherapy 2, 1
• Mix the PRP and non-crosslinked HA in equal proportions immediately before injection in a single syringe 1

Alternative Approach: PRF May Be Superior to PRP

• Platelet-rich fibrin (PRF) demonstrates a 3-fold higher therapeutic response when combined with procedures compared to PRP 3
• PRF shows superiority over PRP specifically for canthal smoothness and wrinkles at 3 months, though other parameters remain similar 2
• PRF stimulates over 2-fold improvement in collagen synthesis in vitro compared to standard approaches 2

Treatment Protocol

Standard Regimen for Skin Rejuvenation

• Administer three treatment sessions spaced at minimum 21-day intervals 2
• Provide maintenance treatments every 6 months thereafter 2
• Counsel patients on sun protection and smoking cessation to optimize outcomes 2

Delivery Methods (in order of effectiveness)

1. Intradermal injection of HA-PRP mixture for volumization and rejuvenation 2
2. Microneedling with APCs for minimally invasive delivery using depths of 0.25-2.5mm 2, 3
3. Topical application post-procedure (least effective as standalone) 2

Enhanced Combination Strategies

RF Microneedling + PRP/PRF

• Combining radiofrequency microneedling with PRP significantly improves cutaneous spots, wrinkles, pore reduction, and texture with high patient satisfaction 2, 3
• This combination produces superior outcomes compared to RF microneedling alone 3
• Apply APCs immediately after RF treatment, not before, as pre-treatment application causes cell damage 2

Nanofat + PRF for Advanced Rejuvenation

• A large RCT of 103 patients showed nanofat plus intradermal liquid-PRF injection maintained significant skin quality enhancement at 12 months, while HA injection controls lost significance 2
• This combination achieves over 90% overall satisfaction rate and superior improvement in facial texture compared to traditional HA transplants 2

Safety Profile and Advantages

Why This Approach Prioritizes Patient Outcomes

• No serious adverse events reported with HA-PRP combination therapy 1
• Better biocompatibility than synthetic fillers alone, reducing risk of allergic reactions and vascular occlusions 1
• More cost-effective than commercial crosslinked fillers while providing natural cells and growth factors for ongoing regeneration 2, 1
• Treatments are generally well tolerated across all studies 2

Critical Pitfalls to Avoid

Timing of Combination Treatments

• Never apply APCs before laser therapy—laser treatment must be performed first, with APCs applied immediately after either topically, via microneedling, or as injectable 2
• This prevents cell damage from ablative laser wavelengths 2

Product Selection Caution

• Avoid internet-purchased dermal fillers administered by non-clinicians, which pose significant safety risks 4
• Use only FDA-approved HA fillers and properly prepared autologous platelet concentrates 5

Protocol Standardization Gap

• Current protocols for APC preparation, dosing, and treatment frequency remain non-standardized 2
• Despite this variability, the 3-treatment protocol with 21-day intervals represents the most consistent evidence-based approach 2

Long-Term Considerations

• Non-crosslinked HA degrades more rapidly than crosslinked formulations, but combination with PRP extends therapeutic benefits through ongoing tissue regeneration 1
• Cross-linking agents can be added to APCs to extend degradation properties similar to commercial fillers (4-6 months duration) while maintaining natural regenerative advantages 2
• Albumin-gel APC formulations (BioFiller) provide 4-6 months longevity while simultaneously building collagen over time 2