Is a dose of 20 units of Lantus (insulin glargine) appropriate for a patient with an overnight blood glucose level of 89/90 mg/dL?

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Blood Glucose 89-90 mg/dL Overnight on Lantus 20 Units: Dose Adjustment Needed

Your current Lantus dose of 20 units is appropriate and should NOT be reduced, as overnight blood glucose levels of 89-90 mg/dL fall within the optimal target range of 80-130 mg/dL recommended by the American Diabetes Association. 1

Why This Dose is Appropriate

Your fasting glucose values are exactly where they should be:

  • Target fasting glucose range: 80-130 mg/dL 1
  • Your values of 89-90 mg/dL sit comfortably in the middle of this range
  • These readings indicate your basal insulin is properly titrated 1

When to Reduce Lantus Dose

The American Diabetes Association provides clear criteria for dose reduction:

  • Reduce by 2 units only if more than 2 fasting glucose values per week are LESS than 80 mg/dL 1
  • Your readings of 89-90 mg/dL do not meet this threshold
  • If you experience hypoglycemia (glucose <70 mg/dL) without clear cause, reduce dose by 10-20% immediately 1

Critical Monitoring Points

Continue checking your fasting glucose daily and watch for these warning signs:

  • Hypoglycemia symptoms: shakiness, sweating, confusion, or glucose readings <70 mg/dL 1
  • Nocturnal hypoglycemia: night sweats, nightmares, morning headaches 1
  • If either occurs, reduce your Lantus dose by 10-20% and contact your healthcare provider 1

When to Increase Your Dose

If your situation changes, consider dose adjustment:

  • Increase by 2 units every 3 days if fasting glucose is 140-179 mg/dL 1
  • Increase by 4 units every 3 days if fasting glucose is ≥180 mg/dL 1
  • Continue titration until fasting glucose consistently reaches 80-130 mg/dL 1

Important Caveats

Do not make changes based on single readings. The American Diabetes Association recommends assessing glucose patterns over several days, not reacting to individual values 1. Your consistent readings of 89-90 mg/dL represent stable, well-controlled fasting glucose.

Maintain consistent timing. Administer Lantus at the same time each day to maintain stable blood glucose levels 2, 3. Changes in injection timing can affect glycemic control 3.

References

Guideline

Initial Dosing for Lantus (Insulin Glargine) in Patients Requiring Insulin Therapy

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2026

Guideline

Insulin Glargine Dosing and Administration

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2026

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Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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