Wegovy Should Not Be Used If It Has Been Frozen
Do not use Wegovy if it has been frozen, even if it returns to the proper refrigerator temperature of 36-46°F (2-8°C). Freezing can alter the molecular structure of the medication and potentially reduce its efficacy, making it unsafe and ineffective for use 1.
Why Freezing Damages Wegovy
- Freezing compromises the drug's molecular integrity, which is critical for semaglutide's therapeutic action as a GLP-1 receptor agonist 1.
- Injectable medications like Wegovy must be stored according to strict manufacturer guidelines to maintain efficacy and prevent degradation 1.
- Once frozen, the medication cannot be salvaged by simply returning it to proper refrigerator temperatures—the damage is permanent 1.
Proper Storage Requirements
- Store Wegovy at 36-46°F (2-8°C) in the refrigerator at all times until ready for use 1, 2.
- Never freeze the medication—this is the most critical storage rule 1, 2.
- Store centrally in the refrigerator, not in the door or near freezer compartments where temperature zones may inadvertently freeze the medication 2.
- Avoid placement near cold air outlets from freezer compartments in combination refrigerator/freezer units 2.
How to Prevent Accidental Freezing
- Place calibrated thermometers in a central location adjacent to where medications are stored, and document temperatures twice daily 2.
- Take immediate corrective action if temperatures fall outside the 2-8°C range 2.
- Avoid frost-free freezers for any storage, as temperature cycling can compromise stability 2.
- Do not store food or beverages in the same refrigerator as medications to prevent temperature fluctuations 2.
What to Do If Freezing Occurs
- Discard the medication immediately—do not attempt to use it 1.
- Inspect for visible changes including clumping, frosting, precipitation, or changes in clarity or color before each use 1, 2.
- Always check the expiration date before administration 2.
- Contact your pharmacy or healthcare provider for a replacement pen.