Colimex Drops Dosing Information Not Available in Provided Evidence
I cannot provide a specific dosing recommendation for "Colimex drops" for a 3.5 kg baby because none of the provided evidence contains information about a product called "Colimex drops."
Important Clarification Needed
The term "Colimex" does not appear in any of the guideline or research evidence provided. However, the evidence does contain extensive information about colistin (polymyxin E), which is phonetically similar. I must clarify what medication is actually being requested:
If This is Colistin (Antibiotic):
For a 3.5 kg neonate requiring IV colistin for multidrug-resistant gram-negative infections, the dose would be 2.5-5 mg colistin base activity (CBA)/kg/day IV divided into 2 or 4 doses 1.
- For a 3.5 kg infant, this calculates to 8.75-17.5 mg CBA per day total, divided into 2-4 doses 1
- This would be approximately 4.4-8.75 mg CBA per dose if given twice daily 1
- Maximum single dose is 100 mg CBA 1
Critical safety considerations for colistin in neonates:
- Colistin has significant nephrotoxicity risk, particularly in critically ill patients 2
- Renal function must be monitored closely 2
- Colistin should only be used for confirmed multidrug-resistant gram-negative infections when no other options exist 3, 4
- Oral colistin is NOT recommended for neonates as it can lead to colistin-resistant intestinal flora 5
If This is NOT Colistin:
You must verify the exact product name and active ingredient. "Colimex" may be:
- A brand name for simethicone/dicyclomine (for infant colic)
- A regional brand name for another medication
- A compounded preparation
Without knowing the actual medication and its active ingredients, I cannot provide safe dosing guidance for this 3.5 kg infant.