Can I combine Tapentadol (Palexia) with Gamma-Aminobutyric Acid (GABA)?

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From the Research

Combination of Tapentadol and Gamma-Aminobutyric Acid (GABA)

  • There is no direct evidence to suggest the combination of Tapentadol (Palexia) with Gamma-Aminobutyric Acid (GABA) in the provided studies.
  • However, a study on the combination of pregabalin and tapentadol showed a synergistic antihypersensitive effect in a rat model of neuropathic pain 1.
  • Pregabalin does not bind to GABA receptors, but it is used to treat neuropathic pain conditions, and its mechanism of action is not yet fully understood 2.
  • Tapentadol has been shown to be effective in managing chronic pain, including neuropathic pain, and has a unique analgesic profile due to its noradrenergic mechanism of action 3, 4.
  • The combination of tapentadol with other drugs, such as pregabalin, has been shown to be beneficial in treating neuropathic pain, but the specific combination with GABA has not been studied 1.

References

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