What is the typical starting dose of Baclofen (GABA receptor agonist) for a patient, considering factors such as age, weight, renal function, and presence of comorbidities?

For a patient requiring Baclofen, a typical starting dose could be 5 mg three times a day, with the potential for gradual increases as needed and tolerated, up to a maximum of 80 mg per day. This recommendation is cautious and considers the potential for adverse effects, especially in vulnerable populations such as the elderly or those with significant comorbidities. The patient's age, weight, renal function, and the presence of other health conditions should be taken into account when determining the appropriate dose. In pediatric patients, the dose is often adjusted based on weight. It's also important to consider the potential for drug interactions, especially with other central nervous system depressants. If the patient does not respond adequately to Baclofen or experiences significant side effects, alternative treatments such as Tizanidine or Diazepam might be considered, though each has its own set of potential side effects and interactions that must be carefully weighed. Ultimately, the decision on Baclofen dosing should be made on an individual basis, taking into account the specific clinical context and the goal of minimizing morbidity and mortality.