What is Venclexta (Venetoclax)?

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Last updated: April 16, 2025 • View editorial policy

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From the Guidelines

Vascenra is not mentioned in the provided evidence, however, based on the context of the question, it seems that the question is referring to Venetoclax, a medication used in the treatment of certain types of cancer, including chronic lymphocytic leukemia (CLL) and acute myeloid leukemia (AML).

Treatment Overview

The treatment of relapsed and refractory disease should consider the patient's comorbidities, comedication, access, and preference.

  • For relapse after CIT, BTKis or venetoclax-rituximab should be considered equally, depending on the above factors 1.
  • Patients who relapse after CIT or with a late relapse (at least 36 months) after venetoclax-based, time-limited therapy and without a TP53 mutation or del(17p) should be treated with one of the following options:
    • Venetoclax-rituximab for 24 months
    • Acalabrutinib or zanubrutinib as continuous therapy
    • Ibrutinib as continuous therapy (acalabrutinib and zanubrutinib are preferred over ibrutinib)
    • Ibrutinib-venetoclax (not EMA approved, not FDA approved in relapse) 1.

Dosing and Administration

The dosing and administration of venetoclax vary depending on the specific treatment regimen and the patient's response to therapy.

  • The standard dosing of venetoclax begins at 20 mg daily for 1 week, then increases to 50 mg daily for 1 week, 100 mg daily for 1 week, and finally to 400 mg daily 1.
  • Venetoclax should be administered orally, with a glass of water, and can be taken with or without food.

Side Effects and Monitoring

The most common side effects of venetoclax include neutropenia, infection, anemia, and thrombocytopenia.

  • Patients should be monitored regularly for signs of tumor lysis syndrome (TLS), including blood chemistries, electrolyte imbalances, and renal function 1.
  • Aggressive monitoring and management of TLS are crucial to minimize the risk of this potentially life-threatening complication.

Quality of Life

The quality of life (QoL) outcomes in patients with AL amyloidosis are significantly impacted by the disease and its treatment.

  • Studies have shown that QoL indicators, such as the Short Form Health Survey (SF36), are appropriate proxies for disease severity and diagnostics 1.
  • The 6-min walking test (6MWT) is a valid prognostic tool for AL amyloidosis patients' survival, but its predictive value is limited in patients with short life expectancy 1.

From the Research

Vascenra Overview

  • Vascenra is not directly mentioned in the provided studies, however, the studies discuss various antihypertensive therapies and their effectiveness in managing hypertension and cardiovascular diseases.

Antihypertensive Therapies

  • The study 2 analyzed real clinical practice data from the National Registry of Arterial Hypertension and found that combination therapy is often prescribed for patients with hypertension and concomitant diseases.
  • The study 3 discussed the effect of statins on blood pressure regulation and found that statins can have a hypotensive effect, particularly in patients with untreated hypertension or those treated with angiotensin-converting enzyme inhibitors and calcium channel blockers.
  • The study 4 reviewed the clinical pharmacology of combination therapies for the prevention and treatment of cardiovascular diseases, including fixed combination therapies such as rosuvastatin/ezetimibe and ramipril/amlodipine.

Comparison of Antihypertensive Medications

  • The study 5 compared outcomes and adverse events between angiotensin-converting enzyme (ACE) inhibitors and angiotensin receptor blockers (ARBs) in patients with hypertension and found no difference in efficacy, but ACE inhibitors were associated with more adverse events.
  • The study 6 investigated the association between the type of prior antihypertensive medication use and the likelihood of cardiovascular events in hypertensive African-American and Non-Hispanic Caucasian patients, and found that calcium channel blockers (CCBs) had a lower cardiovascular event risk than ACE inhibitors, ARBs, or diuretics.

Treatment Considerations

  • The studies suggest that the choice of antihypertensive medication should be based on individual patient characteristics, including comorbidities and racial background.
  • Combination therapy may be effective in managing hypertension and cardiovascular diseases, particularly in patients with concomitant diseases.
  • Fixed combination therapies may simplify treatment and improve patient adherence.

References

1
Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

3
Research

Statins and blood pressure regulation.

Current hypertension reports, 2001

5
Research

Angiotensin-Converting Enzyme Inhibitors in Hypertension: To Use or Not to Use?

Journal of the American College of Cardiology, 2018

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Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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