From the Research
Januvia (sitagliptin) can cause constipation in some patients, though it's not among the most common side effects, and the most recent and highest quality study does not specifically address the incidence of constipation with Januvia. The mechanism of Januvia, which involves increasing incretin levels to regulate blood sugar, may affect gut motility in some individuals, potentially leading to constipation 1. If you experience constipation while taking Januvia, staying well-hydrated, increasing dietary fiber, and regular physical activity may help alleviate symptoms. A study on fiber supplementation found that it can be effective in improving constipation, particularly with psyllium, doses >10 g/d, and treatment durations of at least 4 weeks 2. Another study found that psyllium supplementation decreased constipation symptoms, body weight, glycemic, cholesterol, and increased HDL levels in patients with type 2 diabetes and chronic constipation 3. However, if constipation becomes severe or persistent, you should consult your healthcare provider, as they might recommend adjusting your medication regimen or adding treatments specifically for constipation. Don't stop taking Januvia without medical advice, as maintaining diabetes control remains important.
Some key points to consider:
- Januvia's effect on gut motility may contribute to constipation in some patients
- Increasing dietary fiber, staying hydrated, and regular physical activity may help alleviate constipation symptoms
- Psyllium supplementation has been shown to be effective in improving constipation
- If constipation persists, consult your healthcare provider for further guidance
- Maintaining diabetes control is crucial, and any changes to medication should be done under medical supervision.
It's also important to note that while the provided studies do not directly address the incidence of constipation with Januvia, they do provide insight into the potential effects of the medication on gut motility and the effectiveness of fiber supplementation in improving constipation symptoms 1, 2, 3.