From the Guidelines
No, if you miss the second dose of the HPV vaccine, you do not need to restart the entire series. You should simply get the missed dose as soon as possible, and then continue with the recommended schedule from that point. For the standard HPV vaccination series, there are typically 2 or 3 doses depending on the age when vaccination begins. According to the recommendations of the Advisory Committee on Immunization Practices (ACIP) 1, if the quadrivalent HPV vaccine schedule is interrupted, the vaccine series does not need to be restarted.
- If the series is interrupted after the first dose, the second dose should be administered as soon as possible, and the second and third doses should be separated by an interval of at least 12 weeks.
- If only the third dose is delayed, it should be administered as soon as possible. This approach is consistent with general vaccination principles where interrupted schedules don't require restarting the series. However, for optimal protection against HPV-related diseases including certain cancers, it's essential to complete the full series even if doses are delayed. The vaccine works by stimulating your immune system to produce antibodies against HPV, and completing all recommended doses ensures the strongest and most durable immune response, as noted in the ACIP recommendations 1.
From the Research
HPV Vaccination Schedule
- The HPV vaccination schedule typically consists of two or three doses, depending on the age of the individual and the specific vaccine used 2, 3.
- Studies have shown that a two-dose schedule can provide satisfactory immunological outcomes in adolescent girls, and is now recommended for youth ages 9 to 14 years 3, 4.
Missed Doses
- If an individual misses a dose of the HPV vaccine, it is not necessary to restart the entire series 5.
- However, it is important to complete the vaccine series as soon as possible to ensure optimal protection against HPV infection and associated diseases 5, 3.
Vaccine Effectiveness
- The HPV vaccine has been shown to be highly effective in preventing HPV infection and associated diseases, including cervical cancer 2, 6.
- The vaccine is most effective when administered before sexual debut, but catch-up campaigns have also been shown to be beneficial in reducing HPV infection and disease 6.
Special Considerations
- Individuals who have missed a dose of the HPV vaccine should consult with their healthcare provider to determine the best course of action for completing the vaccine series 5.
- Healthcare providers should be aware of the latest vaccine recommendations and updates to ensure that individuals receive the most effective and efficient vaccination schedule possible 4.